Sustained endothelial expression of HoxA5 in vivo impairs pathological angiogenesis and tumor progression.
HoxA5 is expressed in quiescent endothelial cells (EC), but absent here in activated angiogenic EC.To examine the efficacy of targeting HoxA5 therapeutically to quell pathologic or tumor angiogenesis, we generated an inducible, transgenic mouse model of sustained HoxA5 expression in ECs.During pathologic angiogenesis, sustained HoxA5 regulates expr